Show simple item record Mthembu, Nonkululeko N. Mbita, Zukile Hull, Rodney Dlamini, Zodwa 2019-10-10T10:23:41Z 2019-10-10T10:23:41Z 2017
dc.identifier.issn 1179-1373
dc.description Journal article published in the Journal of HIV/AIDS - Research and Palliative Care 2017:9 77–93 en_US
dc.description.abstract Alternative splicing of mRNA leads to an increase in proteome biodiversity by allowing the generation of multiple mRNAs, coding for multiple protein isoforms of various structural and functional properties from a single primary pre-mRNA transcript. The protein isoforms produced are tightly regulated in normal development but are mostly deregulated in various cancers. In HIV-infected individuals with AIDS, there is an increase in aberrant alternative splicing, resulting in an increase in HIV/AIDS-related cancers, such as Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and cervical cancer. This aberrant splicing leads to abnormal production of protein and is caused by mutations in cis-acting elements or trans-acting factors in angiogenesis-related genes. Restoring the normal regulation of alternative splicing of angiogenic genes would alter the expression of protein isoforms and may confer normal cell physiology in patients with these cancers. This review highlights the abnormalities in alternative splicing of angiogenesis-related genes and their implication in HIV/AIDS-related cancers. This allows us to gain an insight into the pathogenesis of HIV/AIDS-related cancer and in turn elucidate the therapeutic potential of alternatively spliced genes in HIV/AIDS-related malignancies. en_US
dc.format.extent 17 pages en_US
dc.language.iso en en_US
dc.publisher HIV/AIDS - Research and Palliative Care en_US
dc.relation.requires Adobe Acrobat Reader en_US
dc.subject Vascular endothelial growth factor en_US
dc.subject Oncogenic viruses en_US
dc.subject Hypoxia induced factor 1 en_US
dc.subject Kaposi’s sarcoma en_US
dc.subject Non-Hodgkin’s lymphoma en_US
dc.subject Therapies targeting alternative splicing en_US
dc.subject HIV related cancers en_US
dc.subject.lcsh Blood-vessels -- Growth en_US
dc.subject.lcsh Oncogenic viruses en_US
dc.subject.lcsh Kaposi's sarcoma en_US
dc.subject.lcsh Vascular endothelial growth factors en_US
dc.subject.lcsh Lymphomas en_US
dc.subject.lcsh Cervix uteri -- Cancer en_US
dc.title Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers en_US
dc.type Article en_US

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