Show simple item record Lekalakala, M. R Said, M Dangor, Y Mbelle, N Sihlabela, A Ismail, F 2019-11-18T08:51:48Z 2019-11-18T08:51:48Z 2018
dc.identifier.issn 0256-9574
dc.identifier.issn 2078-5135
dc.description Article published in the SAMJ South African Medical Journal 2018;108(12):1032-1035. DOI:10.7196/SAMJ.2018.v108i12.13079 en_US
dc.description.abstract Background. Group B streptococcus (GBS) is a leading cause of invasive disease, particularly in newborns. Seventy-five percent of neonates will be colonised by mothers carrying the organism. Confirmation of maternal colonisation with GBS is essential for prompt treatment and prevention of neonatal sepsis. The current gold standard of culture for isolation of GBS has a disadvantage of long turnaround time (24 - 72 hours). Rapid assays are required to determine maternal carriage of GBS. Objectives. To determine the usefulness of the Xpert GBS technology v. culture methods to detect GBS carriage in pregnant women. Methods. This was a prospective observational study of 284 pregnant women between 26 and 37 weeks’ gestation. Two vaginorectal swabs were collected from each participant. One swab was processed using the gold-standard culture method, while the second swab was processed using the Xpert GBS assay. The performance of the Xpert GBS assay was then compared with that of the culture method. Results. Two swabs were processed from each of 284 pregnant women between 26 and 37 weeks’ gestation. Culture detected 70 GBS isolates from a total of 279 specimens (25.1%), whereas the Xpert GBS detected 66 positive specimens (23.7%). The Xpert GBS assay had a sensitivity of 87% and specificity of 98%, with a positive predictive value of 92% and a negative predictive value of 96%. Conclusions. The Xpert GBS assay is a rapid and sensitive tool for prenatal detection of GBS. The assay should ideally be available in every labour ward, where women can be screened for GBS on arrival. en_US
dc.format.extent 04 pages en_US
dc.language.iso en en_US
dc.publisher SAMJ South African Medical Journal en_US
dc.relation.requires pdf en_US
dc.subject Comparison en_US
dc.subject Xpert GBS v. culture en_US
dc.subject Detection en_US
dc.subject Group B streptococcus en_US
dc.subject Pregnant women en_US
dc.subject Sensitivity en_US
dc.subject Specificity en_US
dc.subject Predictive values en_US
dc.subject.lcsh Pregnant women en_US
dc.subject.lcsh Neonatal intensive care en_US
dc.title Comparison of Xpert GBS v. culture for rapid detection of group B streptococcus in pregnant women: Sensitivity, specificity and predictive values en_US
dc.type Article en_US

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