Abstract:
Background: This study was designed to determine the relationship of
immunohistochemical subtypes of breast cancer and clinicopathological features and
demographic information in Limpopo since there has been no data published on the
association of immunohistochemical subtypes, clinicopathological features and
demographic characteristics in recent years.
Methods: Data was obtained from records of patients diagnosed with breast cancer
between 2015 and 2020. Chi-Square and ANOVA tests were performed, and results
considered significant at p ≤ 0.05.
Results: The mean age was 50.32 ± 11.40, estrogen receptor positive(ER+),
progesterone receptor positive(PR+) and human epidermal growth receptor 2
positive(HER2+) prevalence were 73.5%, 62.3% and 26.5% respectively. More than
half of the patients (54.3%) had a Ki-67 level >15%. Grade II tumors were the
predominant type of tumors in this study (51.7%). 43.7% of the cases showed lymph
node involvement. Luminal B subtype was the most predominant
immunohistochemical subtype in the study (46.4%), followed by Luminal A (24.5 %),
TNBC (19.9%) and HER2- enriched (6.6%). 2.6 % of the cases were classified as
undetermined.
Conclusion: A significant association was observed between immunohistochemical
subtypes and tumor grade
