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dc.contributor.advisor Torres, MDC Zelaya
dc.contributor.advisor Sedumedi, Barbara Rankapole, Ruth Khutso 2013-03-05T06:42:28Z 2013-03-05T06:42:28Z 2013 2011
dc.description Thesis(M Med (Haematology)) -- University of Limpopo, 2011. en_US
dc.description.abstract BACKGROUND: Multiple myeloma (MM) is a rare age-related disorder with increasing incidence with advancing age. It is a B-cell malignancy characterised by monoclonal expression and accumulation of abnormal plasma cells in the bone marrow. It comprises about 1 % of all malignant tumours worldwide and 10% of haemopoietic neoplasms. MM accounted for 0.43% of newly diagnosed malignancies in South Africa in 1999 and Visser et al (2009), found the incidence to be 0.00054%. Mwambakana in 2000 at Ga-Rankuwa Hospital, now known as Dr George Mukhari Hospital (DGMH), found MM to be the commonest haematological malignancy. No clear risk factors have been identified in this disease. The natural history of MM is one of progressive bone destruction, refractory cytopenias and end-organ damage. The diagnosis and staging of MM is based on different criteria and systems. OBJECTIVES: To establish a profile of patients diagnosed with MM at DGMH from 1 January 2004 to 31 December 2009. METHODS: We conducted a descriptive retrospective review of medical records of patients diagnosed and treated for MM at DGMH from 2004-2009. RESULTS: Thirty-four patients' records were found. MM was found to be present in these patients as early as the third decade, more females than males were diagnosed and females were surviving longer than their male counterparts. Clinical features were not significantly different from those previously reported. The WHO 2001 diagnostic criteria created by Durie & Salmon and the International Staging System were used more frequently and most patients presented at an advanced stage of the disease. en_US
dc.language.iso en en_US
dc.publisher University of Limpopo (Medunsa Campus) en_US
dc.relation.requires Adobe Acrobat Reader, version 6.0 en_US
dc.subject Multiple myeloma en_US
dc.title The Occurence of multiple myeloma at Dr George Mukhari Hospital, Gauteng: a retrospective review (2004-2009) en_US
dc.type Thesis en_US

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