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Browsing School of Physical and Mineral Sciences by Author

Browsing School of Physical and Mineral Sciences by Author "Nxumalo, W."

Now showing items 1-11 of 11

Buchwald coupling of quinoxaline-o-sulfonates leading to the heterocyclic compounds with potential medicinal properties against TB

Ramakadi, Tselane Geneva (University of Limpopo, 2018)

The dissertation describes the use of 2-benzenesulfonyloxyquinoxaline as a good coupling partner for different amine substrates. The palladium-mediated cross- coupling of aryl electrophiles and amines has become a widely ...
Design and synthesis of quinoxaline derivatives for medicinal application against breast cancer cells

Lekgau, Karabo (2021)

Breast cancer is a malignant tumour that starts in the cells of the breast. Many studies revealed aromatase (CYP19A1) and cyclin-dependent kinase 2 (CDK2) as possible therapeutic targets regarding breast cancer treatment, ...
Design and synthesis of quinoxaline derivatives for medicinal application against breast cancer cells

Lekgau, Karabo (2021)

Breast cancer is a malignant tumour that starts in the cells of the breast. Many studies revealed aromatase (CYP19A1) and cyclin-dependent kinase 2 (CDK2) as possible therapeutic targets regarding breast cancer treatment, ...
Isolation and characterisation of antifungal compounds from medicinal plants that are active against selected fusarium species

Seepe, Hlabana Alfred (2021)

Fusarium species are among pathogenic organisms responsible for massive yield and quality losses in crop production. They cause crop diseases in the field and during storage, and some species are capable of producing ...
Novel synthetic routs towards the synthesis of mono-, di- and tri-substituted qunoxallines

Ndlovu, Ndumiso Thamsanqa (University of Limpopo, 2016)

2-Benzenesulfonyloxyquinoxaline was prepared following literature procedure followed by palladium-catalysed Negishi coupling reactions to yield the corresponding, 2-mono-substituted quinoxaline derivatives, 2-phenylquinoxaline ...
Profiling of plant extracts (crotion gratissimus and leonotis leonurus) for their activity against mycobacterium tuberculosis and isolation and charecterisation of the active compounds

Maifo, Bochilo Pleasure (2021)

Tuberculosis is one of the top 10 leading causes of death in the world. The development of drug resistant strains of Mycobacterium tuberculosis such as Multidrug resistant (MDR) and Extensively drug resistant (XDR) strains ...
Sonogashira coupling of quinoxaline-o-sulfonates leading to heterocyclic compounds with potential medicinal properties against TB

Mokgoathana, Herman Dikosha (2015)

Alkyne-quinoxaline compounds were successfully synthesised form the cross-coupling of 2-benzenesulfonyloxyquinoxaline with terminal alkynes. The current study demonstrates the ability of benzenesulfonyloxy as a good leaving ...
Synthesis and biological activity of schiff based and ruthenium P-Cymene complexes containing ethynylpyridine bridged to quinazoline derivatives

Dilebo, Kabelo Bramley (2019)

Imidazolyl-ethanamine Schiff base ligands of the N^N type were prepared by condensation reaction of histamine dihydrochloride with para-substituted aldehyde derivatives to yield: (E)-N-benzylidene-2-(1H-imidazol-4-yl)ethanamine ...
Synthesis of quinoxaline compounds and their medicinal properties against mycobacterium tuberculosis

Raphoko, Lerato Augustinah (2019)

In an attempt to synthesise quinoxaline-ferrocene compounds with antimycobacterial activity; a series of quinoxaline alkynyl derivatives were successfully synthesised from 3- (quinoxalin-3-yl)prop-2-yn-1-ol 86A and ...
Synthesis,characterisation and biological activity studies of organo-bridged metal schiff base complexes with qinoxaline derivative

Mohlala, Reagan Lehlogonolo (University of Limpopo, 2016)

Imidazolyl-salicylaldemine Schiff base ligands were prepared by the condensation of different substituted salicylaldehydes with histamine dihydrochloride: 2,4-di-tert-butyl-6-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl}-phenol ...
Synthesis,characterisation and biological activity studies of organo-bridged metal schiff base complexes with qinoxaline derivative

Mohlala, Reagan Lehlogonolo (University of Limpopo, 2016)

Imidazolyl-salicylaldemine Schiff base ligands were prepared by the condensation of different substituted salicylaldehydes with histamine dihydrochloride: 2,4-di-tert-butyl-6-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl}-phenol ...

Browsing School of Physical and Mineral Sciences by Author "Nxumalo, W."

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